Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia

Population Pharmacokinetic Modeling and Pharmacodynamic Target Attainment Simulation of Piperacillin/Tazobactam for Dosing Optimization in Late Elderly Patients with Pneumonia

The aim of this study was to develop a population pharmacokinetic model for piperacillin (PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the administration planning by applying pharmacokinetic/pharmacodynamic (PK/PD) criteria. PIPC/TAZ (total dose of 2.25 or 4.5 g) wa...

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Bibliographic Details
Main Authors: Noriyuki Ishihara, Nobuhiro Nishimura, Kazuro Ikawa, Fumi Karino, Kiyotaka Miura, Hiroki Tamaki, Takahisa Yano, Takeshi Isobe, Norifumi Morikawa, Kohji Naora
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Antibiotics
Subjects:
piperacillin
tazobactam
late elderly patients
pneumonia
population pharmacokinetic/pharmacodynamic analysis
Online Access:https://www.mdpi.com/2079-6382/9/3/113

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https://www.mdpi.com/2079-6382/9/3/113

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