Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2<i>H</i>)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker

Novel twenty-three 3(2<i>H</i>)-pyridazinone derivatives were designed and synthesized based on the chemical requirements related to the anti-proliferative effects previously demonstrated within this scaffold. The introduction of a piperazinyl linker between the pyridazinone nucleus and...

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Bibliographic Details
Main Authors: Mehmet Abdullah Alagöz, Zeynep Özdemir, Mehtap Uysal, Simone Carradori, Marialucia Gallorini, Alessia Ricci, Susi Zara, Bijo Mathew
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/14/3/183