Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase‐3‐mediated cleavage of the AML1‐ETO oncoprotein

Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase‐3‐mediated cleavage of the AML1‐ETO oncoprotein

Abstract Homoharringtonine combined with aclarubicin and cytarabine (HAA) is a highly effective treatment for acute myeloid leukemia (AML), especially for t(8;21) AML. However, the underlying mechanisms by which HAA kills t(8;21) AML cells remain unclear. In this study, SKNO‐1 and Kasumi‐1 cells wit...

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Bibliographic Details
Main Authors: Jiang Cao, Hao Feng, Ning‐Ning Ding, Qing‐yun Wu, Chong Chen, Ming‐Shan Niu, Wei Chen, Ting‐Ting Qiu, Hong‐Hu Zhu, Kai‐Lin Xu
Format: Article
Language:English
Published: Wiley 2016-11-01
Series:Cancer Medicine
Subjects:
Acute myeloid leukemia
AML1‐ETO
homoharringtonine combined with aclarubicin and cytarabine
synergistic
Online Access:https://doi.org/10.1002/cam4.913

Internet

https://doi.org/10.1002/cam4.913

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