Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis

Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis

Prognosis of gastric and esophageal cancer is poor and treatment improvements are needed. Programmed cell death 1 receptor (PD-1) interaction with its ligand PD-L1 in tumor micro-environment promotes immune tolerance and blocking monoclonal antibodies have entered clinical practice. However, clinica...

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Bibliographic Details
Main Authors: Silvio Däster, Serenella Eppenberger-Castori, Valentina Mele, Hannah M. Schäfer, Lukas Schmid, Benjamin Weixler, Savas D. Soysal, Raoul A. Droeser, Giulio C. Spagnoli, Christoph Kettelhack, Daniel Oertli, Luigi Terracciano, Luigi Tornillo, Urs von Holzen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Medicine
Subjects:
gastric cancer
esophageal cancer
PD-1
PD-L1
CD8+ lymphocyte infiltration
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00144/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00144/full

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