Depletion of HIV reservoir by activation of ISR signaling in resting CD4+ T cells

Depletion of HIV reservoir by activation of ISR signaling in resting CD4+ T cells

Summary: HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4+ T cell model of latency without effect on HIV-negative CD...

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Bibliographic Details
Main Authors: Dajiang Li, Lilly M. Wong, Yuyang Tang, Brigitte Allard, Katherine S. James, George R. Thompson, Satya Dandekar, Edward P. Browne, Qingsheng Li, Jeremy M. Simon, Nancie M. Archin, David M. Margolis, Guochun Jiang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Immunology
Virology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222020168

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222020168

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