Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

Abstract Background Emergence of resistance against integrase inhibitor raltegravir in human immunodeficiency virus type 1 (HIV-1) patients is generally associated with selection of one of three signature mutations: Y143C/R, Q148K/H/R or N155H, representing three distinct resistance pathways. The me...

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Main Authors: Axel Fun, Thomas Leitner, Linos Vandekerckhove, Martin Däumer, Alexander Thielen, Bernd Buchholz, Andy I. M. Hoepelman, Elizabeth H. Gisolf, Pauline J. Schipper, Annemarie M. J. Wensing, Monique Nijhuis
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Retrovirology
Online Access:http://link.springer.com/article/10.1186/s12977-017-0384-z

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http://link.springer.com/article/10.1186/s12977-017-0384-z

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