Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome
CRISPR-Cas systems protect bacteria and archaea from phages and other mobile genetic elements, which use small anti-CRISPR (Acr) proteins to overcome CRISPR-Cas immunity. Because Acrs are challenging to identify, their natural diversity and impact on microbial ecosystems are underappreciated. To ove...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-09-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/46540 |