Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex

Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex

Abstract Background Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fibrosis in severe asthma. However, the role of the HDAC2/Sin3A/methyl-CpG...

Full description

Bibliographic Details
Main Authors: Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Han-Pin Kuo, Bing-Chang Chen, Chien-Huang Lin
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Biomedical Science
Subjects:
HDAC2
Sin3A
MeCP2
ET-1
CTGF
Airway fibrosis
Online Access:https://doi.org/10.1186/s12929-023-00931-5

Internet

https://doi.org/10.1186/s12929-023-00931-5

Similar Items