Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex

Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex

Abstract Background Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fibrosis in severe asthma. However, the role of the HDAC2/Sin3A/methyl-CpG...

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Bibliographic Details
Main Authors:	Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Han-Pin Kuo, Bing-Chang Chen, Chien-Huang Lin
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Series:	Journal of Biomedical Science
Subjects:	HDAC2 Sin3A MeCP2 ET-1 CTGF Airway fibrosis
Online Access:	https://doi.org/10.1186/s12929-023-00931-5

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