Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease

Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease

Deubiquitinating enzymes (DUBs) are a group of proteases that are important for maintaining cell homeostasis by regulating the balance between ubiquitination and deubiquitination. As the only known metalloproteinase family of DUBs, JAB1/MPN/Mov34 metalloenzymes (JAMMs) are specifically associated wi...

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Bibliographic Details
Main Authors: Xin Pan, Sihua Wu, Wenping Wei, Zixuan Chen, Yong Wu, Kaizheng Gong
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomolecules
Subjects:
deubiquitinating enzymes
JAMMs
structural basis
catalytic mechanism
functions
inhibitors
Online Access:https://www.mdpi.com/2218-273X/12/7/910

Internet

https://www.mdpi.com/2218-273X/12/7/910

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