Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers

Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers

The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiotherapy herald new opportunities for classical oxygen-...

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Autori principali: Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P. Hay
Natura: Articolo
Lingua:English
Pubblicazione: MDPI AG 2023-05-01
Serie:Molecules
Soggetti:
chemoradiotherapy
DNA damage
electron affinity
hypoxia
nitroimidazole
prodrugs
Accesso online:https://www.mdpi.com/1420-3049/28/11/4457

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https://www.mdpi.com/1420-3049/28/11/4457

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