Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration

Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration

Oxidative stress-associated retinal pigment epithelium (RPE) cell death is critically implicated in the pathogenesis of visual dysfunction and blindness of retinal degenerative diseases. Sodium iodate (NaIO<sub>3</sub>) is an oxidative retinotoxin and causes RPE damage. Previously, we fo...

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Bibliographic Details
Main Authors: Chi-Ming Chan, Ponarulselvam Sekar, Duen-Yi Huang, Shu-Hao Hsu, Wan-Wan Lin
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antioxidants
Subjects:
sodium iodate (NaIO<sub>3</sub>)
AMP-activated protein kinase (AMPK)
mitochondrial fission
mitochondrial respiration
Online Access:https://www.mdpi.com/2076-3921/9/11/1057

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https://www.mdpi.com/2076-3921/9/11/1057

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