The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development

The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development

Abstract Background Choroid plexuses regulate the exchanges between the blood and the CSF, and provide trophic factors necessary to brain development. They also express detoxifying enzymes that protect the developing brain from harmful substances. Targeting the Nuclear factor (erythroid-derived 2)-l...

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Bibliographic Details
Main Authors: Nathalie Strazielle, Karen Silva, Emmanuel Rault, Cindy Durand, Elodie Saudrais, Pascal Mein, Sandrine Blondel, Anne Denuzière, Jean-François Ghersi-Egea
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Choroid plexus
Nrf2
Glutathione-S-transferases
Neuroprotection
Postnatal development
Online Access:https://doi.org/10.1186/s12987-025-00622-3

Internet

https://doi.org/10.1186/s12987-025-00622-3

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