Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice

Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice

Objective: Aging and chronic glucocorticoid excess share a number of critical features, including the development of central obesity, insulin resistance and osteoporosis. Previous studies have shown that skeletal glucocorticoid signalling increases with aging and that osteoblasts mediate the detrime...

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Bibliographic Details
Main Authors: Holger Henneicke, Sarah Kim, Michael M. Swarbrick, Jingbao Li, Sylvia J. Gasparini, Joanne Thai, Daphne Foong, Lauryn L. Cavanagh, Colette Fong-Yee, Elisabeth Karsten, Ruby C.Y. Lin, Mark S. Cooper, Hong Zhou, Markus J. Seibel
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
Glucocorticoid
Aging
Osteoblast
Osteocyte
Obesity
Leptin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301721

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http://www.sciencedirect.com/science/article/pii/S2212877820301721

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