Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

Fibrillin-1 mutation contributes to Marfan syndrome by inhibiting Cav1.2-mediated cell proliferation in vascular smooth muscle cells

ABSTRACTMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutation in fibrillin-1 (FBN1). However, the molecular mechanism underlying MFS remains poorly understood. The study aimed to explore how the L-type calcium channel (CaV1.2) modulates disease progression of M...

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Bibliographic Details
Main Authors: Wenfeng Lin, Jiaqi Xiong, Yefan Jiang, Hao Liu, Jinhui Bian, Juejin Wang, Yongfeng Shao, Buqing Ni
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Channels
Subjects:
Marfan Syndrome
Cav1.2
FBN1
cell proliferation
cell cycle
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2023.2192377

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2023.2192377

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