Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

Abstract An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy. We hypothesized that a conjugate vaccine based on...

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Bibliographic Details
Main Authors: Danielle Nettere, Shakthi Unnithan, Nicole Rodgers, Junsuke Nohara, Paul Cray, Madison Berry, Caroline Jones, Lawrence Armand, Shuk Hang Li, Stella J. Berendam, Genevieve G. Fouda, Derek W. Cain, Taylor N. Spence, Joshua A. Granek, Clemontina A. Davenport, Robert J. Edwards, Kevin Wiehe, Koen K. A. Van Rompay, M. Anthony Moody, Sallie R. Permar, Justin Pollara
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00775-y

Internet

https://doi.org/10.1038/s41541-023-00775-y

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