Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors

Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors

IntroductionThe vascular endothelial growth factor receptor 2 (VEGFR-2) and the mesenchymal-epithelial transition factor (c-Met) are critical in the pathogenesis and progression of various cancers by synergistically contributing to angiogenesis and tumor progression. The development of dual-target i...

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Bibliographic Details
Main Authors: Junmin Dong, Xiaohua Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
VEGFR-2
c-Met
pharmacophore
molecular docking
MD simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1534707/full

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https://www.frontiersin.org/articles/10.3389/fphar.2025.1534707/full

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