Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum

Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum

PurposeBiomarkers used for predicting longitudinal cognitive change in Alzheimer’s disease (AD) continuum are still elusive. Tau pathology, neuroinflammation, and neurodegeneration are the leading candidate predictors. We aimed to determine these three aspects of biomarkers in cerebrospinal fluid (C...

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Bibliographic Details
Main Authors: Yi-He Chen, Rong-Rong Lin, Hui-Feng Huang, Yan-Yan Xue, Qing-Qing Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
β-amyloid
brain atrophy
p-tau181
cognition change
sTREM2
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.848180/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.848180/full

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