T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution
Abstract Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to un...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
|
| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-024-02960-w |
| _version_ | 1797272752325918720 |
|---|---|
| author | Wenhui Yang Shimao Liu Mengyun Mao Yandong Gong Xiaohui Li Tianyu Lei Chao Liu Shikai Wu Qinyong Hu |
| author_facet | Wenhui Yang Shimao Liu Mengyun Mao Yandong Gong Xiaohui Li Tianyu Lei Chao Liu Shikai Wu Qinyong Hu |
| author_sort | Wenhui Yang |
| collection | DOAJ |
| description | Abstract Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing (scRNA-seq) allows the high-resolution analysis of the precise composition of immune cells with different phenotypes and other microenvironmental factors, including non-immune stromal cells and the related molecules in the tumor microenvironment of various cancer types. In this review, we summarized the research progress on T-cell infiltration and the crosstalk of other stromal cells and cytokines during T-cell infiltration using scRNA-seq to provide insights into the mechanisms regulating T-cell infiltration and contribute new perspectives on tumor immunotherapy. |
| first_indexed | 2024-03-07T14:34:37Z |
| format | Article |
| id | doaj.art-477c42240542404d928ac62adb54daad |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-03-07T14:34:37Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-477c42240542404d928ac62adb54daad2024-03-05T20:43:31ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662024-02-0143111810.1186/s13046-024-02960-wT-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolutionWenhui Yang0Shimao Liu1Mengyun Mao2Yandong Gong3Xiaohui Li4Tianyu Lei5Chao Liu6Shikai Wu7Qinyong Hu8Department of Oncology, Renmin Hospital of Wuhan UniversityDepartment of Oncology, Renmin Hospital of Wuhan UniversityDepartment of Oncology, Renmin Hospital of Wuhan UniversityState Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General HospitalDepartment of Medical Oncology, Peking University First HospitalDepartment of Oncology, Renmin Hospital of Wuhan UniversityDepartment of Radiation Oncology, Peking University First HospitalDepartment of Medical Oncology, Peking University First HospitalDepartment of Oncology, Renmin Hospital of Wuhan UniversityAbstract Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain immune cells can impair this response and help tumor immune escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand tumor immunity and improve therapeutic effect of cancer immunotherapy. The use of single-cell RNA sequencing (scRNA-seq) allows the high-resolution analysis of the precise composition of immune cells with different phenotypes and other microenvironmental factors, including non-immune stromal cells and the related molecules in the tumor microenvironment of various cancer types. In this review, we summarized the research progress on T-cell infiltration and the crosstalk of other stromal cells and cytokines during T-cell infiltration using scRNA-seq to provide insights into the mechanisms regulating T-cell infiltration and contribute new perspectives on tumor immunotherapy.https://doi.org/10.1186/s13046-024-02960-wSingle-cell RNA sequencingTumor microenvironmentT-cell infiltration“hot tumors” and “cold tumors”Stromal cells |
| spellingShingle | Wenhui Yang Shimao Liu Mengyun Mao Yandong Gong Xiaohui Li Tianyu Lei Chao Liu Shikai Wu Qinyong Hu T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution Journal of Experimental & Clinical Cancer Research Single-cell RNA sequencing Tumor microenvironment T-cell infiltration “hot tumors” and “cold tumors” Stromal cells |
| title | T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution |
| title_full | T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution |
| title_fullStr | T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution |
| title_full_unstemmed | T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution |
| title_short | T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution |
| title_sort | t cell infiltration and its regulatory mechanisms in cancers insights at single cell resolution |
| topic | Single-cell RNA sequencing Tumor microenvironment T-cell infiltration “hot tumors” and “cold tumors” Stromal cells |
| url | https://doi.org/10.1186/s13046-024-02960-w |
| work_keys_str_mv | AT wenhuiyang tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT shimaoliu tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT mengyunmao tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT yandonggong tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT xiaohuili tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT tianyulei tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT chaoliu tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT shikaiwu tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution AT qinyonghu tcellinfiltrationanditsregulatorymechanismsincancersinsightsatsinglecellresolution |