Mechanisms of life cycle simplification in African trypanosomes

Abstract African trypanosomes are important parasites in sub-Saharan Africa that undergo a quorum-sensing dependent development to morphologically ‘stumpy forms’ in mammalian hosts to favour transmission by tsetse flies. However, some trypanosome clades have simplified their lifecycle by escaping de...

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Bibliographic Details
Main Authors: Guy R. Oldrieve, Frank Venter, Mathieu Cayla, Mylène Verney, Laurent Hébert, Manon Geerts, Nick Van Reet, Keith R. Matthews
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54555-w