Alkaloid Derivative (<i>Z</i>)-3β-Ethylamino-Pregn-17(20)-en Inhibits Triple-Negative Breast Cancer Metastasis and Angiogenesis by Targeting HSP90α

Alkaloid Derivative (<i>Z</i>)-3β-Ethylamino-Pregn-17(20)-en Inhibits Triple-Negative Breast Cancer Metastasis and Angiogenesis by Targeting HSP90α

Metastasis is an important cause of cancer-related death. Previous studies in our laboratory found that pregnane alkaloids from <i>Pachysandra terminalis</i> had antimetastatic activity against breast cancer cells. In the current study, we demonstrated that treatment with one of the alka...

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Bibliographic Details
Main Authors: Xin-Yao Liu, Yu-Miao Wang, Xiang-Yu Zhang, Mei-Qi Jia, Hong-Quan Duan, Nan Qin, Ying Chen, Yang Yu, Xiao-Chuan Duan
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
compound <b>1</b>
triple-negative breast cancer
antimetastasis
antiangiogenesis
HSP90α
HIF-1α/VEGF/VEGFR2
Online Access:https://www.mdpi.com/1420-3049/27/20/7132

Internet

https://www.mdpi.com/1420-3049/27/20/7132

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