Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells.

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells.

HIV-1 is a complex retrovirus that uses host machinery to promote its replication. Understanding cellular proteins involved in the multistep process of HIV-1 infection may result in the discovery of more adapted and effective therapeutic targets. Kinases and phosphatases are a druggable class of pro...

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Bibliographic Details
Main Authors: Sylvie Rato, Sara Maia, Paula M Brito, Leonor Resende, Carina F Pereira, Catarina Moita, Rui P Freitas, José Moniz-Pereira, Nir Hacohen, Luis Ferreira Moita, Joao Goncalves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2822867?pdf=render

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http://europepmc.org/articles/PMC2822867?pdf=render

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