TSPphg Lysin from the Extremophilic <i>Thermus</i> Bacteriophage TSP4 as a Potential Antimicrobial Agent against Both Gram-Negative and Gram-Positive Pathogenic Bacteria

TSPphg Lysin from the Extremophilic <i>Thermus</i> Bacteriophage TSP4 as a Potential Antimicrobial Agent against Both Gram-Negative and Gram-Positive Pathogenic Bacteria

New strategies against antibiotic-resistant bacterial pathogens are urgently needed but are not within reach. Here, we present in vitro and in vivo antimicrobial activity of TSPphg, a novel phage lysin identified from extremophilic <i>Thermus</i> phage TSP4 by sequencing its whole genome...

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Bibliographic Details
Main Authors: Feng Wang, Xinyu Ji, Qiupeng Li, Guanling Zhang, Jiani Peng, Jun Hai, Yao Zhang, Baiquan Ci, Hongwei Li, Yan Xiong, Xianyu Deng, Lianbing Lin
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Viruses
Subjects:
bacteriophage
endolysin
thermostable lytic protein
antibiotic-resistant bacteria
antimicrobial drug
<i>staphylococcus aureus</i>
skin infection
Online Access:https://www.mdpi.com/1999-4915/12/2/192

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https://www.mdpi.com/1999-4915/12/2/192

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