Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer

Cancer cells preferentially accumulate iron (Fe) relative to non-malignant cells; however, the underlying rationale remains elusive. Iron–sulfur (Fe–S) clusters are critical cofactors that aid in a wide variety of cellular functions (e.g., DNA metabolism and electron transport). In this article, we...

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Bibliographic Details
Main Authors: Michael S. Petronek, Douglas R. Spitz, Bryan G. Allen
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/10/9/1458