Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions

Zoledronate/Anti-VEGF Neutralizing Antibody Combination Administration Increases Osteal Macrophages in a Murine Model of MRONJ Stage 0-like Lesions

The pathophysiology, pathogenesis, histopathology, and immunopathology of medication-related osteonecrosis of the jaw (MRONJ) Stage 0 remain unclear, although 50% of MRONJ Stage 0 cases could progress to higher stages. The aim of this study was to investigate the effects of zoledronate (Zol) and ant...

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Bibliographic Details
Main Authors: Haruka Kaneko, Shinichiro Kuroshima, Ryohei Kozutsumi, Farah A. Al-Omari, Hiroki Hayano, Kazunori Nakajima, Takashi Sawase
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Journal of Clinical Medicine
Subjects:
osteal macrophage
angiogenesis inhibitor
zoledronate
wound healing
tooth extraction
Online Access:https://www.mdpi.com/2077-0383/12/5/1914

Internet

https://www.mdpi.com/2077-0383/12/5/1914

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