Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer

Summary: Chromosome instability (CIN) contributes to resistance to therapies and tumor evolution. Although natural killer (NK) cells can eliminate cells with complex karyotypes, high-CIN human tumors have an immunosuppressive phenotype. To understand which CIN-associated molecular features alter imm...

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Bibliographic Details
Main Authors: Sridhar Kandala, Maria Ramos, Lena Voith von Voithenberg, Alberto Diaz-Jimenez, Sara Chocarro, Johanna Keding, Benedikt Brors, Charles D. Imbusch, Rocio Sotillo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012780

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723012780

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