The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease

Abstract An impairment of amyloid β-peptide (Aβ) clearance is suggested to play a key role in the pathogenesis of sporadic Alzheimer’s disease (AD). Amyloid degradation is mediated by various mechanisms including fragmentation by enzymes like neprilysin, matrix metalloproteinases (MMPs) and a recent...

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Bibliographic Details
Main Authors: Tunahan Kirabali, Serena Rigotti, Alessandro Siccoli, Filip Liebsch, Adeola Shobo, Christoph Hock, Roger M. Nitsch, Gerhard Multhaup, Luka Kulic
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Pericyte
Aβ34
Amyloid clearance
Online Access:https://doi.org/10.1186/s40478-019-0846-8

Internet

https://doi.org/10.1186/s40478-019-0846-8

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