Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I

Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I

Beta hemoglobinopathies are widely spread monogenic lethal diseases. Delta-globin gene activation has been proposed as a possible approach for curing these pathologies. The therapeutic potential of delta-globin, the non-alpha component of Hemoglobin A2 (α2δ2; HbA2), has been demonstrated in a mouse...

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Bibliographic Details
Main Authors: Maria Francesca Manchinu, Michela Simbula, Cristian Antonio Caria, Ester Musu, Lucia Perseu, Susanna Porcu, Maristella Steri, Daniela Poddie, Jessica Frau, Eleonora Cocco, Laura Manunza, Susanna Barella, Maria Serafina Ristaldi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Medicine
Subjects:
erythropoiesis
δ-globin gene
interferon type 1
beta thalassemia
sickle cell anemia
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00163/full

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https://www.frontiersin.org/article/10.3389/fmed.2020.00163/full

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