PFKFB3 Regulates Chemoresistance, Metastasis and Stemness via IAP Proteins and the NF-κB Signaling Pathway in Ovarian Cancer

PFKFB3 Regulates Chemoresistance, Metastasis and Stemness via IAP Proteins and the NF-κB Signaling Pathway in Ovarian Cancer

Glycolysis has been reported to be critical for cancer stem cells (CSCs), which are associated with tumor chemoresistance, metastasis and recurrence. Thus, selectively targeting glycolytic enzymes may be a potential therapy for ovarian cancer. 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (P...

Full description

Bibliographic Details
Main Authors: Yu-xin Jiang, Michelle K. Y. Siu, Jing-jing Wang, Thomas H. Y. Leung, David W. Chan, Annie N. Y. Cheung, Hextan Y. S. Ngan, Karen K. L. Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
PFKFB3
stemness
PFK158
therapeutic target
ovarian cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.748403/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.748403/full

Similar Items