Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile

Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile

Donepezil nasal delivery strategies are being continuously investigated for advancing therapy in Alzheimer’s disease. The aim of this study was to develop a chitosan-based, donepezil-loaded thermogelling formulation tailored to meet all the requirements for efficient nose-to-brain delivery. A statis...

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Bibliographic Details
Main Authors: Mirna Perkušić, Laura Nižić Nodilo, Ivo Ugrina, Drago Špoljarić, Cvijeta Jakobušić Brala, Ivan Pepić, Jasmina Lovrić, Maša Safundžić Kučuk, Marie Trenkel, Regina Scherließ, Dijana Zadravec, Livije Kalogjera, Anita Hafner
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceutics
Subjects:
donepezil
chitosan
nose-to-brain delivery
thermoresponsive in situ gelling system
3D nasal cavity model
olfactory deposition
Online Access:https://www.mdpi.com/1999-4923/15/6/1660

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https://www.mdpi.com/1999-4923/15/6/1660

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