In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis

In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis

Osteoarthritis is a degenerative arthropathy that is mainly characterized by dysregulation of inflammatory responses. KMUP-1, a derived chemical synthetic of xanthine, has been shown to have anti-inflammatory and antioxidant properties. Here, we aimed to investigate the in vitro anti-inflammatory an...

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Bibliographic Details
Main Authors: Shang-En Huang, Erna Sulistyowati, Yu-Ying Chao, Bin-Nan Wu, Zen-Kong Dai, Jong-Hau Hsu, Jwu-Lai Yeh
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomedicines
Subjects:
xanthine-derived KMUP-1
anti-inflammation
NF-κB
SIRT1
osteoarthritis
Online Access:https://www.mdpi.com/2227-9059/9/6/615

Internet

https://www.mdpi.com/2227-9059/9/6/615

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