Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse

Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse

Type 2 diabetes is associated with diabetic cognopathy. Anti-hyperglycemic sodium glucose transporter 2 (SGLT2) inhibitors have shown promise in reducing cognitive impairment in mice with type 2 diabetes mellitus. We recently described marked ultrastructural (US) remodeling of the neurovascular unit...

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Bibliographic Details
Main Authors: Melvin R. Hayden, DeAna G. Grant, Annayya R. Aroor, Vincent G. DeMarco
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Brain Sciences
Subjects:
astrocyte
endothelial cell
microglia
mitochondria
myelin
neuroglia
oligodendrocyte
pericyte
sodium glucose co-transporter 2 inhibitor (SGLT2i)
white matter
Online Access:http://www.mdpi.com/2076-3425/9/3/57

Internet

http://www.mdpi.com/2076-3425/9/3/57

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