Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells

Leukotriene B4 (LTB4) biosynthesis by polymorphonuclear leukocytes (PMNs) is an important factor of inflammatory responses. PMNs also release LTA4, an unstable intermediate that can be taken up by neighboring cells and metabolized into LTC4. Most studies of LT synthesis have been carried out using h...

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Bibliographic Details
Main Authors: Miguel A. Gijón, Simona Zarini, Robert C. Murphy
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752043247X