Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration

Asymmetric Synthesis of Both Enantiomers of Dimethyl 2-Methylsuccinate by the Ene-Reductase-Catalyzed Reduction at High Substrate Concentration

Chiral dimethyl 2-methylsuccinate (<b>1</b>) is a very important building block for the manufacturing of many active pharmaceutical ingredients and fine chemicals. The asymmetric reduction of C=C double bond of dimethyl citraconate (<b>2</b>), dimethyl mesaconate (<b>3&...

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Bibliographic Details
Main Authors: Jiacheng Li, Jianjiong Li, Yunfeng Cui, Min Wang, Jinhui Feng, Peiyuan Yao, Qiaqing Wu, Dunming Zhu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Catalysts
Subjects:
dimethyl citraconate
dimethyl itaconate
dimethyl mesaconate
dimethyl 2-methylsuccinate
enantioselective enzymatic reduction
ene-reducase
Online Access:https://www.mdpi.com/2073-4344/12/10/1133

Internet

https://www.mdpi.com/2073-4344/12/10/1133

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