The N-Terminal Part of the 1A Domain of Desmin Is a Hot Spot Region for Putative Pathogenic <i>DES</i> Mutations Affecting Filament Assembly
Desmin is the major intermediate filament protein of all three muscle cell types, and connects different cell organelles and multi-protein complexes such as the cardiac desmosomes. Several pathogenic mutations in the <i>DES</i> gene cause different skeletal and cardiac myopathies. Howeve...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/23/3906 |