Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

Abstract Genomic instability represents a typical feature of aggressive cancers. Normal cells have evolved intricate responses to preserve genomic integrity in response to stress, such as DNA damage induced by γ-irradiation. Cyclin-dependent kinases (CDKs) take crucial part to these safeguard mechan...

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Bibliographic Details
Main Authors: Stefania Berton, Martina Cusan, Ilenia Segatto, Francesca Citron, Sara D’Andrea, Sara Benevol, Michele Avanzo, Alessandra Dall’Acqua, Monica Schiappacassi, Robert G. Bristow, Barbara Belletti, Gustavo Baldassarre
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-00734-3

Internet

https://doi.org/10.1038/s41598-017-00734-3

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