Secretome of Stressed Peripheral Blood Mononuclear Cells Alters Transcriptome Signature in Heart, Liver, and Spleen after an Experimental Acute Myocardial Infarction: An In Silico Analysis

Secretome of Stressed Peripheral Blood Mononuclear Cells Alters Transcriptome Signature in Heart, Liver, and Spleen after an Experimental Acute Myocardial Infarction: An In Silico Analysis

Acute myocardial infarction (AMI) is a result of cardiac non-perfusion and leads to cardiomyocyte necrosis, inflammation, and compromised cardiac performance. Here, we showed that the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCsec) improved heart function in a porcine AMI mode...

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Bibliographic Details
Main Authors: Caterina Selina Mildner, Dragan Copic, Matthias Zimmermann, Michael Lichtenauer, Martin Direder, Katharina Klas, Daniel Bormann, Alfred Gugerell, Bernhard Moser, Konrad Hoetzenecker, Lucian Beer, Mariann Gyöngyösi, Hendrik Jan Ankersmit, Maria Laggner
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biology
Subjects:
therapeutic secretome
PBMC secretome
acute myocardial infarction
regenerative medicine
ischemia/reperfusion
paracrine action
Online Access:https://www.mdpi.com/2079-7737/11/1/116

Internet

https://www.mdpi.com/2079-7737/11/1/116

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