The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi

The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi

Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process. GBF1 contains a conserved, catalytic, Sec7 domain (Sec7d) and five additional (DCB, HUS, HDS1-3) domains. He...

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Bibliographic Details
Main Authors: Justyna M. Meissner, Katarina Akhmetova, Tomasz Szul, Ekaterina G. Viktorova, Bingdong Sha, Jay M. Bhatt, Eunjoo J. Lee, Richard A. Kahn, George A. Belov, Igor Chesnokov, Elizabeth Sztul
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Sec 7 guanine nucleotide exchange factor
GBF1
Golgi
HDS3 domain
ARF
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1233272/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1233272/full

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