Synaptic protein CSF levels relate to memory scores in individuals without dementia

Synaptic protein CSF levels relate to memory scores in individuals without dementia

Abstract Background We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. Methods We included 242 CN (105(43%) abnormal...

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Bibliographic Details
Main Authors: Kirsten E. J. Wesenhagen, Diederick M. de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B. Smit, Lars Bertram, Charlotte E. Teunissen, Henrik Zetterberg, Betty M. Tijms, Pieter Jelle Visser, the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Synaptic proteins
Cerebrospinal fluid proteomics
Memory performance
Early Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13195-025-01703-z

Internet

https://doi.org/10.1186/s13195-025-01703-z

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