Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions

Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions

Abstract Early identification of genetic risk factors for complex diseases can enable timely interventions and prevent serious outcomes, including mortality. While the genetics underlying many Mendelian diseases have been elucidated, it is harder to predict risk for complex diseases arising from the...

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Bibliographic Details
Main Authors: Segun Fatumo, Dassen Sathan, Chaimae Samtal, Itunuoluwa Isewon, Tsaone Tamuhla, Chisom Soremekun, James Jafali, Sumir Panji, Nicki Tiffin, Yasmina Jaufeerally Fakim
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Genome Medicine
Subjects:
Polygenic risk scores
Africa
Genetic diversity
Genomic architecture
Complex diseases
Online Access:https://doi.org/10.1186/s13073-023-01245-9

Internet

https://doi.org/10.1186/s13073-023-01245-9

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