Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages

Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages

Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is known to induce endoplasmic reticulum (ER) stress i...

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Bibliographic Details
Main Authors: Junichi Ishiyama, Ryoko Taguchi, Yunike Akasaka, Saiko Shibata, Minoru Ito, Michiaki Nagasawa, Koji Murakami
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Journal of Lipid Research
Subjects:
palmitic acid
endoplasmic reticulum
fatty acid
low density lipoprotein receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520405255

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http://www.sciencedirect.com/science/article/pii/S0022227520405255

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