Reactivity of bromoselenophenes in palladium-catalyzed direct arylations
The reactivity of 2-bromo- and 2,5-dibromoselenophenes in Pd-catalyzed direct heteroarylation was investigated. From 2-bromoselenophene, only the most reactive heteroarenes could be employed to prepare 2-heteroarylated selenophenes; whereas, 2,5-dibromoselenophene generally gave 2,5-di(heteroarylate...
| Hlavní autoři: | , , , |
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| Médium: | Článek |
| Jazyk: | English |
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Beilstein-Institut
2017-12-01
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| Edice: | Beilstein Journal of Organic Chemistry |
| Témata: | |
| On-line přístup: | https://doi.org/10.3762/bjoc.13.278 |
| Shrnutí: | The reactivity of 2-bromo- and 2,5-dibromoselenophenes in Pd-catalyzed direct heteroarylation was investigated. From 2-bromoselenophene, only the most reactive heteroarenes could be employed to prepare 2-heteroarylated selenophenes; whereas, 2,5-dibromoselenophene generally gave 2,5-di(heteroarylated) selenophenes in high yields using both thiazole and thiophene derivatives. Moreover, sequential catalytic C2 heteroarylation, bromination, catalytic C5 arylation reactions allowed the synthesis of unsymmetrical 2,5-di(hetero)arylated selenophene derivatives in three steps from selenophene. |
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| ISSN: | 1860-5397 |