Proximal tubular epithelia-specific transcriptomics of diabetic mice treated with dapagliflozin

Proximal tubular epithelia-specific transcriptomics of diabetic mice treated with dapagliflozin

Based on recent clinical trials using sodium-glucose co-transporter 2 inhibitor (SGLT2i) demonstrating the significant improvement of outcomes of diabetic kidney disease (DKD), the paradigm shift from “glomerulocentric” to “tubule centric” pathophysiology in DKD progression has been highlighted. Sev...

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Bibliographic Details
Main Authors: Noriko Uehara-Watanabe, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Kunihiro Nakai, Aya Yagi-Tomita, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Heliyon
Subjects:
Diabetic nephropathy
Proximal tubular epithelial cell
Dapagliflozin
Hypoxia
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402201903X

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http://www.sciencedirect.com/science/article/pii/S240584402201903X

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