Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway

Abstract Background Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack of ideal therapeutic strategies for periodontitis that can...

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Bibliographic Details
Main Authors: Shi-Yuan Yang, Yue Hu, Ran Zhao, Yu-Ning Zhou, Yu Zhuang, Yan Zhu, Xiao-Li Ge, Ting-Wei Lu, Kai-Li Lin, Yuan-Jin Xu
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Nanobiotechnology
Subjects:
Periodontitis
Quercetin
Alveolar bone regeneration
Osteoimmunomodulation
Mesoporous bioactive glass
Online Access:https://doi.org/10.1186/s12951-024-02352-4

Internet

https://doi.org/10.1186/s12951-024-02352-4

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