Cardiac Cx43 Signaling Is Enhanced and TGF-β1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHR<sup>M</sup>

Cardiac Cx43 Signaling Is Enhanced and TGF-β1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHR<sup>M</sup>

The hearts of spontaneously hypertensive rats (SHR) are prone to malignant arrhythmias, mainly due to disorders of electrical coupling protein Cx43 and the extracellular matrix. Cold acclimation may induce cardio-protection, but the underlying mechanisms remain to be elucidated. We aimed to explore...

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Bibliographic Details
Main Authors: Katarina Andelova, Barbara Szeiffova Bacova, Matus Sykora, Stanislav Pavelka, Hana Rauchova, Narcis Tribulova
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
hairless SHR<sup>M</sup>
cold acclimation
cardiac Cx43
extracellular matrix
thyroid hormones
Online Access:https://www.mdpi.com/2227-9059/10/7/1707

Internet

https://www.mdpi.com/2227-9059/10/7/1707

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