Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

Mammalian cells can generate ATP via glycolysis or mitochondrial respiration. Oncogene activation and hypoxia promote glycolysis and lactate secretion. The significance of these metabolic changes to ATP production remains however ill defined. Here, we integrate LC‐MS‐based isotope tracer studies wit...

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Bibliographic Details
Main Authors: Jing Fan, Jurre J Kamphorst, Robin Mathew, Michelle K Chung, Eileen White, Tomer Shlomi, Joshua D Rabinowitz
Format: Article
Language:English
Published: Springer Nature 2013-01-01
Series:Molecular Systems Biology
Subjects:
cancer bioenergetics
isotope tracing
metabolic flux analysis
Online Access:https://doi.org/10.1038/msb.2013.65

Internet

https://doi.org/10.1038/msb.2013.65

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