Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation

Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation

Newly differentiated pancreatic β cells lack proper insulin secretion profiles of mature functional β cells. The global gene expression differences between paired immature and mature β cells have been studied, but the dynamics of transcriptional events, correlating with temporal development of gluco...

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Bibliographic Details
Main Authors: Tiziana Sanavia, Chen Huang, Elisabetta Manduchi, Yanwen Xu, Prasanna K. Dadi, Leah A. Potter, David A. Jacobson, Barbara Di Camillo, Mark A. Magnuson, Christian J. Stoeckert, Guoqiang Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
β-cell maturation
glucose-induced insulin secretion
vesicle release
calcium influx
time-series gene expression
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.648791/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.648791/full

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