Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits.

In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy fiber inputs from dentate gyrus granule cells. The neuromodulators acetylcholine and noradrenaline are separately proposed as...

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Bibliographic Details
Main Authors: Luke Y Prince, Travis Bacon, Rachel Humphries, Krasimira Tsaneva-Atanasova, Claudia Clopath, Jack R Mellor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-10-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1009435