New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showi...

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Bibliographic Details
Main Authors: Anna Carbone, Barbara Parrino, Maria Grazia Cusimano, Virginia Spanò, Alessandra Montalbano, Paola Barraja, Domenico Schillaci, Girolamo Cirrincione, Patrizia Diana, Stella Cascioferro
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Marine Drugs
Subjects:
marine alkaloids
nortopsentin analogues
thiazole derivatives
anti-virulence agents
antibiofilm agents
Online Access:http://www.mdpi.com/1660-3397/16/8/274

Internet

http://www.mdpi.com/1660-3397/16/8/274

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