GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer

GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer

Abstract Practice of tumor-targeted suicide gene therapy is hampered by unsafe and low efficient delivery of plasmid DNA (pDNA). Using HIV-Tat-derived peptide (Tat) to non-covalently form Tat/pDNA complexes advances the delivery performance. However, this innovative approach is still limited by intr...

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Bibliographic Details
Main Authors: Linjia Su, Zhe Sun, Fangzheng Qi, Huishan Su, Luomeng Qian, Jing Li, Liang Zuo, Jinhai Huang, Zhilin Yu, Jinping Li, Zhinan Chen, Sihe Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Nanobiotechnology
Subjects:
Macropinocytosis
Cell-cycle
Glucose-regulated protein
Tat/pDNA-Ca2+ nanoparticle
Suicide gene therapy
Ovarian cancer
Online Access:https://doi.org/10.1186/s12951-022-01530-6

Internet

https://doi.org/10.1186/s12951-022-01530-6

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